Global efforts are underway for mitigation and adaptation to combat climate change and global warming. The focus of the policymakers and the governments has been to reduce greenhouse gas (GHG) emissions by shifting the energy mix from non-renewable to renewable sources of energy. However, there are other areas that provide strong reasons to attract the attention of experts, policymakers, and governments. For instance, extensive use of single-use plastic has also been a great source of concern as it has serious environmental consequences. It is imperative to reduce the use of plastic, especially disposable ones. The authors investigate the determinants of the single-use avoidance behavior of the public in Pakistan. For this purpose to serve, the authors developed a questionnaire survey and collected data from more than 400 hundred respondents. In this study, the researchers examined the impact of attitude, subjective norms (SN), and perceived behavior control (PBC) on single-use plastic avoidance behavior (SPAB) while considering the mediating roles of plastic avoidance behavioral intentions (PABI) and plastic related environmental concerns (PREC). The study also examines the policy intervention (PI) and its role in single-use plastic avoidance behavior with the mediating impact of PABI and PREC. The study uses structural equation modeling (SEM) for the analysis. The results of the SEM analysis show that attitude, PBC, and PI significantly determine PABI. Whereas PREC and PABI significantly affect the SPAB. PI has a significant impact on SPAB through the channels of PABI and PREC.  The findings of the study provide profound insight into that policy intervention is pivotal to controlling single-use plastic waste. Comprehensive and pragmatic policy interventions could be helpful in setting PABIs and PECs amongst the public. Public engagement in environmentally-friendly consumption behavior would be productive in reducing plastic waste in the economy.