The article deals with the intermedial vector of the Danube poets' creativity; it also reveals the aesthetic function of art synthesis in the creative practice of the leading representatives of the regional literary landscape (Mykhailo Vasyliuk, Valerii Vykhodtsev, Tamila Kibkalo, Halyna Lysa, Volodymyr Reva, Volodymyr Semeyko). There were identified the means of verbalizing foreign artistic imagery common to the specified circle of authors with the focus on the lexical, genre, and background levels of the musical, pictorial, and choreographic components of the text, as well as the individual expressive and pictorial resources of intermedial poetics as essential factors of the synergistic effect of a lyrical work, its suggestive influence on the recipient. The main attention is focused on the characterization of individual modes of synergy of the artistic world of the Danube poets: the musical code of creative expression of M. Vasyliuk; universalism of V. Vykhodtsev's poetics; harmonization of literary and pictorial correlations in the lyrics of T. Kibkalo. Kibkalo, musical and choreographic components of H. Lysa's pictorial and expressive system; intertextual markers of literary and artistic correlations in the artistic palette of V. Reva's text; polyartistic nature of the author's world picture by V. Semeyko. The significant editions for the cultural and artistic life of the Danube region became the object of the study: V. Vykhodtsev's “Music of the Heart” (Izmail, 2019); a collection of the brightest poets of the southern Odesa region “Between the Danube and the Dniester” (Izmail, 2020), illustrated by Honored Artist of Ukraine Oleksandr Kara; a collection of songs based on poems by T. Kibkalo, “Spring on the Danube” (Izmail, 2027), which was a project of the associate professor of the Izmail State University of the Humanities, famous composer Oleksandr Zatynchenko. On the basis of the analysis of the aesthetic function of the synthesis of arts in the works of the Danube poets, it is proved that the intermedial code of creative expression of each of them demonstrates the stereophonic organization of the author's test, and therefore is an organic source of formation of its synergy, an important factor of artistic potential.