Objectives: The paper aims at presenting a project for creating and building a Center of Excellence at the University of Ruse under the title "Sustainable and precision farming and quality production." Other goals of the work are to discuss some best practices in the establishment of centers of excellence in the Danube countries. Prior Work: The establishment of this center takes into account the achievements of the University in the field of agriculture, reflected in numerous articles and research projects as well as the developed scientific capacity which will guarantee the success of all future activities of this structure. Approach: Exploration of the prerequisites for the establishment of the center on the basis of comparisons with similar structures. Results: Prognosis for the benefits from the established center for the development of agriculture in the Danube space in the following directions: creating innovative products, integrated use of resources and scientific achievements to obtain sustainability in agriculture, etc. Implications: The model of the center could be used to build similar structures and partnerships in the field of agriculture. Value: Added value to the development of other sectors related to agriculture: tourism, industry, etc.